BSC-1 growth inhibitor/type beta transforming growth factor is a strong inhibitor of thymocyte proliferation.
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چکیده
منابع مشابه
Transforming growth factor-beta 1 bifunctionally regulates murine macrophage proliferation.
Transforming growth factor-beta (TGF-beta) is a family of polypeptide growth factors with multiple functional activities. Recent studies suggest that TGF-beta is a selective inhibitor of hematopoietic cells. In this report, we study the effect of TGF-beta 1 on the proliferation of murine peritoneal exudate macrophages (PEM) in response to purified murine recombinant granulocyte-macrophage colon...
متن کاملEarly human thymocyte proliferation is regulated by an externally controlled autocrine transforming growth factor-beta 1 mechanism.
Early thymocytes undergo extensive proliferation after their entry into the thymus, but cellular interactions and cytokines regulating this intrathymic step remain to be determined. We analyzed the effects of various T-cell growth factors and cellular interactions on in vitro proliferation of early CD2+CD3/TCR-CD4-CD8- (triple negative [TN]) human thymocytes. Freshly isolated TN cells were then...
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متن کاملEarly Human Thymocyte Proliferation Is Regulated by an Externally Controlled Autocrine Transforming Growth Factor-p1 Mechanism
Early thymocytes undergo extensive proliferation after their entry into the thymus, but cellular interactions and cytokines regulating this intrathymic step remain to be determined. We analyzed the effects of various T-cell growth factors and cellular interactions on in vitro proliferation of early CD2'CD3/TCR-CD4-CD8(triple negative [TN]) human thymocytes. Freshly isolated TN cells were then a...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.15.5531